Klippel-Trenaunay syndrome involves one or both legs, or one or both arms with a noticeable port wine stain of the skin and sometime a size difference in the affected leg or arm. This is usually noted at birth. The diagnosis can be made through history and physical examination, and imaging techniques including MRI. Treatment is generally conservative and based on the patient's symptoms. Possible treatment options include compression garments, anticoagulant therapy, and possible orthopedic procedures.